Therapeutic role of Omega-3 fatty acids in improving PCOS and PCOS related complications
DOI:
https://doi.org/10.54393/df.v1i02.16Abstract
To our insight, despite a few preliminaries investigating the helpful impact of n-3 polyunsaturated unsaturated fats (PUFA) on polycystic ovary disorder (PCOS), not many studies are done to examine the impacts of n-3 PUFA utilization on PCOS inconveniences. In this manner, our point was to write a review to explore the potential impact of omega 3 and related components. An extensive, precise search was led in Embase, MEDLINE/PubMed, Google Scholar, and SCOPUS to recognize n-3 unsaturated fats are helpful for improving PCOS complications. In this review, the effect of omega-3 on PCOS, mechanism of omega 3, omega-3 and insulin obstruction, omega-3 and adipokines, omega-3 and lipid metabolism, omega-3 and endothelial capacity, and omega-3 and hormonal elements are mentioned. There are various systems by which n-3 PUFAs might apply their valuable consequences for PCOS, including weight loss, glycemic and hormonal hemostasis, mitigating, the guideline of adipokine creation, and improvement of endothelial capacity. N-3 PUFAs are promising in easing inconveniences related to PCOS. The majority of the examinations in patients with PCOS showed an improvement in many Pcos related complications by the use of omega-3. Also, positive impacts regarding the improvement of dyslipidemia, guideline of adipokines, guideline of hormonal elements, and upgrade of endothelial capacity are restricted. Accordingly, more preliminaries are justified to examine attractive instruments for explaining the metabolic and hormonal impacts of these specialists in PCOS.
References
Tosatti, J.A., Alves, M.T., Cândido, A.L., Reis, F.M., Araújo, V.E. and Gomes, K.B., Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis. British J. Nutr., 2020. 1-12.https://doi.org/10.1017/S0007114520003207
Faghfoori, Z., Fazelian, S., Shadnoush, M. and Goodarzi, R., Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017. 11, S429-S432.https://doi.org/10.1016/j.dsx.2017.03.030
Akram, M., & Roohi, N. Endocrine correlates of polycystic ovary syndrome in Pakistani women. J. Coll. Physicians Surg. Pak., (2015) 25(1), 22-26.https://www.jcpsp.pk/archive/2015/Jan2015/07.pdf
Patel, S., Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J. steroid biochem. molecular bio., 2018. 182, 27-36. https://doi.org/10.1016/j.jsbmb.2018.04.008
Yousuf, S.D., Rashid, F., Mattoo, T., Shekhar, C., Mudassar, S., Zargar, M.A. and Ganie, M.A., Does the oral contraceptive pill increase plasma intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and tumor necrosis factor-α levels in women with polycystic ovary syndrome: A pilot study. Journal of pediatric and adolescent gynecology, 2017. 30(1), 58-62.https://doi.org/10.1016/j.jpag.2016.06.010
Naderpoor, N., Shorakae, S., de Courten, B., Misso, M.L., Moran, L.J. and Teede, H.J., 2015. Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis. Human reproduction update, 21(5),560-574. https://doi.org/10.1093/humupd/dmv025
Tso, L.O., Costello, M.F., Albuquerque, L.E.T., Andriolo, R.B., Marjoribanks, J. and Macedo, C.R., Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review. Fertility and sterility, 2015. 104(3), pp.542-544. https://doi.org/10.1016/j.fertnstert.2015.05.038
Nasri, H. and Rafieian-Kopaei, M., Metformin: current knowledge. J. res. Med. Sci.: Off. J. Isfahan Uni. Med. Sci., 2014. 19(7), .658. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214027/
Szosland, K., Pawłowicz, P. and Lewiński, A., Prolactin secretion in polycystic ovary syndrome (PCOS). Neuroendocrinology Letters, 2015. 36(1). https://www.nel.edu/userfiles/articlesnew/NEL360115A11.pdf
Rahmani, E., Samimi, M., Ebrahimi, F. A., Foroozanfard, F., Ahmadi, S., Rahimi, M., ... & Asemi, Z. The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein (a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome. Molecular and cellular endocrinology, (2017) 439, 247-255. https://doi.org/10.1016/j.mce.2016.09.008
Khan, A., Karim, N., & Ainuddin, J. A. The triad of PCOS, infertility and metformin. J. Bahria Uni. Med. Dent. Coll., (2019).9(1), 67-71.doi: https://doi.org/10.51985/JBUMDC2018144
Allahbadia, G.N. and Merchant, R., Polycystic ovary syndrome and impact on health. Middle East Fertility Soc. J., 2011.16(1), pp.19-37.https://doi.org/10.1016/j.mefs.2010.10.002
Geetha, V. and Chakravarthula, S.N., Chemical composition and anti-inflammatory activity of Boswellia ovalifoliolata essential oils from leaf and bark. J. forestry res., 2018. 29(2), 373-381. https://doi.org/10.1007/s11676-017-0457-9
Ghasemifard, S., Hermon, K., Turchini, G.M. and Sinclair, A.J., Metabolic fate (absorption, β-oxidation and deposition) of long-chain n-3 fatty acids is affected by sex and by the oil source (krill oil or fish oil) in the rat. British j. nutr., 2015. 114(5), 684-692. https://doi.org/10.1017/S0007114515002457
Gray, B., Steyn, F., Davies, P.S.W. and Vitetta, L., Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. European journal of clinical nutrition, 2013 67(12), 1234-1242.https://doi.org/10.1038/ejcn.2013.197
Albracht-Schulte, K., Kalupahana, N.S., Ramalingam, L., Wang, S., Rahman, S.M., Robert-McComb, J. and Moustaid-Moussa, N., Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update. J. nutr. Biochem., 2018. 58, 1-16. https://doi.org/10.1016/j.jnutbio.2018.02.012
Li, S., Wen, W., Gong, X., Huang, X. and Chen, N., Variation of lipids and fatty acids composition in the tissues of wild devil stinger (Inimicus japonicas) during sexual maturation. Aquaculture and fisheries, 2018. 3(3), 115-121. https://doi.org/10.1016/j.aaf.2018.05.004
Khani, B., Mardanian, F. and Fesharaki, S.J., Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome. J. res. Med. Sci.: off. J. Isfahan Uni. Med. Sci., 2017. 22. doi: 10.4103/jrms.JRMS_644_16
Zhang, X., Wang, H., Yin, P., Fan, H., Sun, L., & Liu, Y. Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. Lipids in health and disease, (2017) 16(1), 1-10. https://doi.org/10.1186/s12944-017-0431-8
Zhu, L., Sha, L., Li, K., Wang, Z., Wang, T., Li, Y., ... & Wang, H. Dietary flaxseed oil rich in omega-3 suppresses severity of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in rats. Lipids in health and disease, (2020) 19(1), 1-16. https://doi.org/10.1186/s12944-019-1167-4
Lepretti, M., Martucciello, S., Burgos Aceves, M.A., Putti, R. and Lionetti, L., 2018. Omega-3 fatty acids and insulin resistance: focus on the regulation of mitochondria and endoplasmic reticulum stress. Nutrients, 10(3), p.350. https://doi.org/10.3390/nu10030350
O'Connor, A., Gibney, J. and Roche, H.M., 2010. Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet. Proceedings of the Nutrition Society, 69(4), pp.628-635.DOI: https://doi.org/10.1017/S0029665110002016
Albracht-Schulte, K., Kalupahana, N.S., Ramalingam, L., Wang, S., Rahman, S.M., Robert-McComb, J. and Moustaid-Moussa, N., Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update. J. nutr. Biochem., 2018. 58, 1-16. https://doi.org/10.1016/j.jnutbio.2018.02.012
Günalan, E., Yaba, A. and Yılmaz, B., 2018. The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review. Journal of the Turkish German Gynecological Association, 19(4), p.220. doi: 10.4274/jtgga.2018.0077
Amini, M., Bahmani, F., Foroozanfard, F., Vahedpoor, Z., Ghaderi, A., Taghizadeh, M., Karbassizadeh, H. and Asemi, Z., 2020. The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Psychosomatic Obstetrics & Gynecology, pp.1-9.https://doi.org/10.1080/0167482X.2018.1508282
Mirmasoumi, G., Fazilati, M., Foroozanfard, F., Vahedpoor, Z., Mahmoodi, S., Taghizadeh, M., Esfeh, N.K., Mohseni, M., Karbassizadeh, H. and Asemi, Z., 2018. The effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes, 126(04), pp.222-228.DOI: 10.1055/s-0043-119751
Escobar-Morreale, H.F., Luque-Ramírez, M. and González, F., 2011. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertility and sterility, 95(3), pp.1048-1058.https://doi.org/10.1016/j.fertnstert.2010.11.036
Calder, P.C., 2017. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45(5), pp.1105-1115.https://doi.org/10.1042/BST20160474
Talari, H.R., Poladchang, S., Hamidian, Y., Samimi, M., Gilasi, H.R., Ebrahimi, F.A. and Asemi, Z., 2018. The effects of omega-3 and vitamin E co-supplementation on carotid intima-media thickness and inflammatory factors in patients with polycystic ovary syndrome. Oman medical journal, 33(6), p.473.doi: 10.5001/omj.2018.88
Jamilian, M., Samimi, M., Mirhosseini, N., Ebrahimi, F.A., Aghadavod, E., Talaee, R., Jafarnejad, S., Dizaji, S.H. and Asemi, Z., 2018. The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. Journal of affective disorders, 238, pp.32-38.https://doi.org/10.1016/j.jad.2018.05.027
Baldani, D.P., Skrgatic, L., Kasum, M., Zlopasa, G., Kralik Oguic, S. and Herman, M., 2019. Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality. Gynecological Endocrinology, 35(5), pp.401-405. https://doi.org/10.1080/09513590.2018.1534096
Farimani, A.R., Hariri, M., Azimi-Nezhad, M., Borji, A., Zarei, S. and Hooshmand, E., 2018. The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Acta diabetologica, 55(7), pp.641-652.https://doi.org/10.1007/s00592-018-1110-6
Kang, Y.E., Kim, J.M., Joung, K.H., Lee, J.H., You, B.R., Choi, M.J., Ryu, M.J., Ko, Y.B., Lee, M.A., Lee, J. and Ku, B.J., 2016. The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in modest obesity and early metabolic dysfunction. PloS one, 11(4), p.e0154003.https://doi.org/10.1371/journal.pone.0154003
Hariri, M., Ghiasvand, R., Shiranian, A., Askari, G., Iraj, B. and Salehi‐Abargouei, A., 2015. Does omega‐3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta‐analysis on randomized controlled clinical trials. Clinical endocrinology, 82(2), pp.221-228.https://doi.org/10.1111/cen.12508
Nadjarzadeh, A., Dehghani-Firouzabadi, R., Daneshbodi, H., Lotfi, M.H., Vaziri, N. and Mozaffari-Khosravi, H., 2015. Effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. Journal of reproduction & infertility, 16(4), p.212.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819211/
Stein, J.D., Andrews, C., Musch, D.C., Green, C. and Lee, P.P., 2016. Sight-threatening ocular diseases remain underdiagnosed among children of less affluent families. Health Affairs, 35(8), pp.1359-1366. https://doi.org/10.1377/hlthaff.2015.1007
Liepa, G.U., Sengupta, A. and Karsies, D., 2008. Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference? Nutrition in clinical practice, 23(1), pp.63-71.https://doi.org/10.1177/011542650802300163
Oner, G. and Muderris, I.I., Efficacy of omega-3 in the treatment of polycystic ovary syndrome. J. Obs. Gynae., 2013. 33(3), 289-291. https://doi.org/10.3109/01443615.2012.751365
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