Therapeutic Effect of Avishan-e-Shirazi (Zataria Multiflora Boiss) Root Extract on Oxidative Stress Markers in Moderate Asthmatic Patients: Therapeutic Effect of Avishan-e-Shirazi

Farah Khanum; Noor Fatima; Noor A Fatima; Sheeza Munawar; Muntaha Jaffar; Atiqa Hassan; Alina Akbar; Misbah Arshad

doi:10.54393/df.v5i2.111

Authors

Farah Khanum University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan
Noor Fatima University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan
Noor A Fatima University of South Asia, Lahore, Pakistan
Sheeza Munawar University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan
Muntaha Jaffar University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan
Atiqa Hassan University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan
Alina Akbar Institute of Southern Punjab, Multan, Pakistan
Misbah Arshad University Institute of Diet and Nutrition Sciences, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/df.v5i2.111

Keywords:

Zataria Multiflora, Oxidative Stress, Asthma, Inflammation, Root Extract

Abstract

Avishan-e-Shirazi (Zataria Multiflora Boiss) is a plant widely recognised for its medicinal and culinary purposes. Objectives: To evaluate the therapeutic effect of plant’s root extract on pulmonary function tests and oxidative stress markers among moderate Asthma tic patients. Methods: A total participant of 66 patients with pulmonary disease, 30-40 age, were selected for the 2-month research trial. Individuals were enrolled and distributed equally in two groups, 33 each. In the control group, 53.8% of individual were man, and 46.2% were women. In the treatment group, 49.1% of participants were man, and 50.9% were women. The groups G₀ was considered as a control group with no root extract, and group G₁ where conventional treatment and root extract were advised to participants. The participants were selected from the Jinnah Hospital, Pakistan. The 5mg/kg/day dried root extract supplements 3 times a day were given to the individuals daily for 2 months. Results: The mean age group of Asthma tic patients enrolled in the study was 35 ± 2.98 years in G_0,and in G_1,it was 34 ± 3.05. The mean BMI was 31.34 and 30.98 kgm^-2 in both groups, respectively. There was a significant improvement in FEV1 levels and MDA enzyme levels with a p-value less than 0.05. The NO₂ levels were also better. Similarly, the enzymes thiolase and SOD levels also improved with a p-value less than 0.05 in the treatment group. Conclusions: The current study concluded that Avishan-e-Shirazi root extract could improve the pulmonary function and inflammation among Asthma patients.

References

Danish MJ. Medical Diagnosis and Management. 12th edition. Karachi, Pakistan: Paramount Books (Pvt.) Ltd.; 2020.

Sabar MF, Akram M, Awan FI, Ghani MU, Shahid M, Iqbal Z et al. Awareness of Asthma Genetics in Pakistan: A review with some recommendations. Advancements in Life Sciences. 2018 Nov; 6(1): 1-0.

Brusselle GG and Koppelman GH. Biologic therapies for severe asthma. New England Journal of Medicine. 2022 Jan; 386(2): 157-71. doi: 10.1056/NEJMra2032506.

Lambrecht BN, Hammad H, Fahy JV. The Cytokines of Asthma. Immunity. 2019 Apr; 50(4): 975-91. doi: 10.1016/j.immuni.2019.03.018.

Mustafa M, Mustafa R, Asif R, Mazhar M, Munir N, Mahmood Z. Pharmaceutical monitoring and care for asthmatic patients management from Lahore city of Pakistan. National Journal of Medical and Health Sciences. 2021; 3(2): 49-58.

Ghani MU, Sabar MF, Shahid M, Awan FI, Akram M. A report on asthma genetics studies in Pakistani population. Advancements in Life Sciences. 2017 Feb; 4(2): 33-8.

Kuruvilla ME, Lee FE, Lee GB. Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clinical Reviews in Allergy & Immunology. 2019 Apr; 56: 219-33. doi: 10.1007/s12016-018-8712-1.

Khan MA. Monthly and seasonal prevalence of asthma and chronic obstructive pulmonary disease in the District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan. The Egyptian Journal of Bronchology. 2022 Dec; 16(1): 63. doi: 10.1186/s43168-022-00166-2.

Jackson DJ, Sykes A, Mallia P, Johnston SL. Asthma exacerbations: origin, effect, and prevention. Journal of Allergy and Clinical Immunology. 2011 Dec; 128(6): 1165-74. doi: 10.1016/j.jaci.2011.10.024.

Holgate ST. Pathogenesis of asthma. Clinical & Experimental Allergy. 2008 Jun; 38(6): 872-97. doi: 10.1111/j.1365-2222.2008.02971.x.

Khazdair MR, Ghorani V, Alavinezhad A, Boskabady MH. Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects. Fundamental & Clinical Pharmacology. 2018 Feb; 32(1): 26-50. doi: 10.1111/fcp.12331.

Khazdair MR, Ghorani V, Alavinezhad A, Boskabady MH. Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial. Journal of Ethnopharmacology. 2020 Feb; 248: 112325. doi: 10.1016/j.jep.2019.112325.

Sajed H, Sahebkar A, Iranshahi M. Zataria multiflora Boiss.(Shirazi thyme)—an ancient condiment with modern pharmaceutical uses. Journal of Ethnopharmacology. 2013 Feb; 145(3): 686-98. doi: 10.1016/j.jep.2012.12.018.

Hosseinzadeh H, Ramezani M, Salmani GA. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. Journal of Ethnopharmacology. 2000 Dec; 73(3): 379-85. doi: 10.1016/S0378-8741(00)00238-5.

Karimi A, Krähmer A, Schulz H, Meiners T. Variation of secondary metabolite profile of Zataria multiflora Boiss. populations linked to geographic, climatic, and edaphic factors. Frontiers in Plant Science. 2020 Jul; 11: 508548. doi: 10.3389/fpls.2020.00969.

Zamani N, Shams M, Nimrouzi M, Zarshenas MM, Foroughi AA, Abarghooei EF et al. The effects of Zataria multiflora Boiss.(Shirazi thyme) on nonalcoholic fatty liver disease and insulin resistance: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine. 2018 Dec; 41: 118-23. doi: 10.1016/j.ctim.2018.09.010.

Mahmoodi M, Koohpeyma F, Saki F, Maleksabet A. The protective effect of Zataria multiflora Boiss. hydroalcoholic extract on TNF-α production, oxidative stress, and insulin level in streptozotocin-induced diabetic rats. Avicenna Journal of Phytomedicine. 2019 Jan; 9(1): 72.

Mahboubi M. Management of acute cough by Zataria multiflora Boiss as an alternative treatment. Journal of Integrative Medicine. 2018 Jan; 16(1): 20-5. doi: 10.1016/j.joim.2017.12.006.

Mortazavi Moghaddam SG, Kianmehr M, Khazdair MR. The possible therapeutic effects of some medicinal plants for chronic cough in children. Evidence-Based Complementary and Alternative Medicine. 2020 Oct; 2020. doi: 10.1155/2020/2149328.

Alavinezhad A, Hedayati M, Boskabady MH. The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients. Avicenna Journal of Phytomedicine. 2017 Nov; 7(6): 531.