Squamous Cell Carcinoma and its Association to different chewing Habits in Punjab, Pakistan

Maria Fareed Siddiqui; Umar Raees; Bilal Hassan

doi:10.54393/df.v2i2.36

Authors

Maria Fareed Siddiqui Department of Pharmacy, The University of Lahore, Lahore, Pakistan
Umar Raees Pakistan Council of Research In Water Resources, Lahore, Pakistan
Bilal Hassan University Institute of Public health, Faculty of Allied Health Sciences, The UNiversity of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/df.v2i2.36

Keywords:

OSCC, tobacco, smoking, alcohol

Abstract

Oral squamous cell carcinoma is the world’s most prevalent and alarming cancerous disorder. Primarily it was found that elderly men are mostly affected by this disease due to tobacco and excessive use of alcohol. However, some studies also show a higher incidence of OSCC among young patients less than 40 years of age. Objective: To assess the risk factors for oral squamous cell carcinoma in Lahore. Methods: A randomized retrospective study was performed at Mayo hospital, Lahore. 52 patients suffering from diagnosed oral squamous cell carcinoma were selected as sample from different districts of Punjab, Pakistan. Data was collected by using pre-tested questionnaire. Results: Among all patients 87.50 % patients were addicted to different habits i.e. smoking (23.07%) and some chewing habits such as Paan (8.65%), Sapari (2.88%), Naswar (16.34%) and some patients were found to be addicted to a combination of factors like (Smoking and Paan 2.88%), (Smoking and Naswar 18.26%), (Smoking and Sapari 3.84%), (Paan and naswar 4.80%) and (Paan and Supari 6.73%). The ages of patients were mostly above than 35 years; only 4 patients were below than 35 years. Conclusion: Present data and measures to gratify and slow down the progress of OSCC are scarce. Steps should be taken to create awareness regarding risk factors of OSCC, early diagnosis and how effective treatment can make a difference.

References

Ali M, Sundaram D. Biopsied oral soft tissue lesions in Kuwait: a six-year retrospective analysis. Medical Principles and Practice. 2012;21(6):569-75.

Choi EJ, Zhang X, Kim HJ, Nam W, Cha IH. Prognosis of gingival squamous cell carcinoma diagnosed after invasive procedures. Asian Pac J Cancer Prev. 2011;12(10):2649-52.

Iguchi H, Hashimoto K, Sunami K, Takayama M, Nakamura A, Yamane H. A case of advanced lateral wall oropharyngeal carcinoma showing complete response to chemotherapy with TS-1. Gan to Kagaku ryoho. Cancer & Chemotherapy. 2003 Jan 1;30(1):101-4.

Kajikawa H, Nario K, Miyahara H. A case of neck metastasis from hypopharyngeal carcinoma successfully treated with TS-1. Gan to Kagaku ryoho. Cancer & Chemotherapy. 2004 Apr 1;31(4):631-4.

Khan MA, Saleem S, Shahid SM, Hameed A, Qureshi NR, Abbasi Z, et al., Prevalence of oral squamous cell carcinoma (OSCC) in relation to different chewing habits in Karachi, Pakistan. Pak J Biochem Mol Biol. 2012;45(2):59-63.

MIRZA D, RAZA G, Basit A, Naqvi K, Ahmed S, Abbasi ZA. Oral Squamous Cell Carcinoma (OSCC) in Karachi City- A retrospective study-A RETROSPECTIVE STUDY. Pakistan Oral & Dental Journal. 2016 Sep 30;36(3).

Ahmed R, Malik S, Khan MF, Khattak MR. Epidemiological and clinical correlates of oral squamous cell carcinoma in patients from north-west Pakistan. J Pak Med Assoc. kolovoz. 2019 Aug 1;69(8):1074-1078.

Siddiqui MF, Yaqoob U. Epidemiology of Squamous Cell Carcinoma in Response to Different Hazardous Chewing Causes in Lahore, Pakistan-a Unicenter study: epidemiology of oral carcinoma in Lahore, Pakistan. Pakistan BioMedical Journal. 2019 Dec 31;2(2).

Anwar N, Pervez S, Chundriger Q, Awan S, Moatter T, Ali TS. Oral cancer: Clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan. Plos one. 2020 Aug 6;15(8):e0236359. https://doi.org/10.1371/journal.pone.0236359

Sahaf R, Naseem N, Anjum R, Nagi AH, Path FR. A study of 89 cases of oral squamous cell carcinoma presenting at Teaching Hospitals of Lahore, Pakistan. JPDA. 2017 Jan;26(01):27.

Mohiuddin S, Fatima N, Hosein S, Hosein M. High risk of malignant transformation of oral submucous fibrosis in Pakistani females: A potential national disaster. J Pak Med Assoc. 2016 Nov 1;66(11):1362-1366.

Akram S, Mirza T, Mirza MA, Qureshi M. Emerging patterns in clinico-pathological spectrum of oral cancers. Pakistan journal of medical sciences. 2013 May;29(3):783-787.

Koduganti RR, Sehrawat S, Reddy PV. Gingival squamous cell carcinoma: A diagnostic impediment. Journal of Indian Society of Periodontology. 2012 Jan;16(1):104-7 doi: 10.4103/0972-124X.94615.

Shenoi R, Devrukhkar V, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian journal of cancer. 2012 Jan 1;49(1):21-6. doi: 10.4103/0019-509X.98910.

Tettamanti L, Caprioglio A, Tecco S, Barello G, Macchi A, Tagliabue A, Levrini L. Oral Squamous Cell Carcinoma in the paediatric patient: a literature review. European journal of paediatric dentistry. 2012 Mar 1;13(1):35-40.

SAHAF R, Naseem N, Anjum R, Nagi A. Oral squamous cell carcinoma: A clinicopathological Study. Pakistan Oral & Dental Journal. 2017 Mar 31;37(1).

Vilas-Boas F, Magro F, Balhau R, Lopes JM, Beça F, Eloy C, Lopes S, Macedo G. Oral squamous cell carcinoma in a Crohn's disease patient taking azathioprine: Case report and review of the literature. Journal of Crohn's and Colitis. 2012 Aug 1;6(7):792-5. doi: 10.1016/j.crohns.2012.03.004.

Wong WM, Parvathaneni U, Jewell PD, Martins RG, Futran ND, Laramore GE, Liao JJ. Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: A case report and review of the literature. Head & neck. 2013 Oct;35(10):E292-8. doi: 10.1002/hed.23155.

Bhurgri Y, Faridi N, Ayub M, Rehman AZ. Lipoma of the bone. JOURNAL-PAKISTAN MEDICAL ASSOCIATION. 2000 May 1;50(5):168-9.

Yosefof E, Hilly O, Stern S, Bachar G, Shpitzer T, Mizrachi A. Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease. Head & neck. 2020 Sep;42(9):2316-2320. doi: 10.1002/hed.26177

Tandon A, Bordoloi B, Jaiswal R, Srivastava A, Singh RB, Shafique U. Demographic and clinicopathological profile of oral squamous cell carcinoma patients of North India: A retrospective institutional study. SRM Journal of Research in Dental Sciences. 2018 Jul 1;9(3):114-118.