Potent Hypoglycemic Phytochemicals from Citrus

Citrus for Diabetes


  • Tayyiba Afzal Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Pakistan
  • Yamin Bibi Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Pakistan
  • Zia ur Rehman Mashwani Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Pakistan
  • Syeda Sobia Gilani Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Pakistan
  • Neelum Naheed Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Pakistan
  • Aqsa Jabeen Department of Botany, University of Agriculture, Faisalabad, Pakistan
  • Raafia Noor Afzal School of Chemistry, University of the Punjab, Lahore, Pakistan




Citrus, Diabetes, Naringenin, Metabolism, Hesperiden, Fruits


In particular, when it comes to the cure and management of chronic diseases, consuming a diet that contain natural products such as; plants is crucial for health promotion. Citrus fruit has been widely consumed and possess nutritional components that supports the management and cure of various disease conditions and the underlying metabolic changes that leads to development of long term serious diseases. Multiple citrus fruit species are analyzed for their curative effect particularly for the diseases that are associated with metabolic alterations such as diabetes, heart burn and dyspepsia. Diabetes is found to be effectively cured and allied health problems are managed by the use of citrus fruits and the specific secondary metabolites found in citrus fruits such has; hesperidin, naringenin and nobiletin. Citrus fruits primarily contain flavonoids, which have a number of advantageous properties for health promotion, especially anti-diabetic effects. Present review enlightened the specific curative potential of citrus fruits and phytochemicals on the living organisms, the potential anti-diabetic efficacy and the metabolic pathway of citrus bioactive compounds hesperidin and naringenin is explained. Mechanistic regulation of metabolic disturbances owing to various disease conditions that are root caused by diabetes are effectively done by the bioactive compounds of citrus fruits. Citrus fruits have matchless benefits when it comes the issues of hyperglycemia, while their antidiabetic effects and have ameliorative effect on diabetes related health problems remain to be verified in detail at molecular and clinical level in forthcoming studies.


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DOI: 10.54393/df.v4i03.78
Published: 2023-12-31

How to Cite

Afzal, T., Bibi, Y., Mashwani, Z. ur R., Gilani, S. S., Naheed, N., Jabeen, A., & Afzal, R. N. (2023). Potent Hypoglycemic Phytochemicals from Citrus: Citrus for Diabetes. DIET FACTOR (Journal of Nutritional and Food Sciences), 4(03), 29–37. https://doi.org/10.54393/df.v4i03.78