Therapeutic Potential of Curcumin in Curcuma Longa

Therapeutic Potential of Curcumin in Curcuma longa


  • Amara Arif University Institute of Dietetics and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Maham Fatima University Institute of Dietetics and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Sana Mehmood University Institute of Dietetics and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan



Curcumin, Therapeutic potential, Poly-phenol, Reactive oxygen species, Anti-oxidant, Anti-inflammatory


Curcumin is a polyphenolic active ingredient found in the Curcuma Longa plant (Turmeric). It is a member of the Zingiberaceae family. Turmeric and its compounds are used to treat a variety of diseases in underdeveloped nations because to their low cost. It's a common ingredient in herbal medicine. As an antioxidant, antifungal, antibacterial, anti-inflammatory, and anti-cancer agent, it has a lot of promise. Diabetes mellitus, arthritis, diabetic microangiopathy, gastro-intestinal illness, psoriasis, diabetic nephropathy, anxiety, bacterial infection, hyperlipidemia, acute cardiac disease and inflammation are only of few the disorders and symptoms for which it is very helpful. Although curcuma longa is safe to use and has no negative effect or any toxic response on human health, it is best known for its positive effect in reducing infertility, lowering blood glucose level, reduce bleeding issue and heavy menstruation in some people. Curcumin is an anti-oxidant that played a vital role in the prevention of many illnesses.


[ ] Bachmeier BE, Melchart D. Therapeutic effects of curcumin—From traditional past to present and future clinical applications. International Journal of Molecular Sciences. 2019 Jan;20(15):3757. doi: 10.3390/ijms20153757.

[ ] Ross SM. Curcuma longa (Theracumin®): A Bioavailable Form of Curcumin and Its Cognitive Benefits. Holistic nursing practice. 2018;32(4):217-20. doi: 10.1097/HNP.0000000000000281.

[ ] Argilashki D, Hadzhieva B. The Benefits Of Curcumin In Various Diseases And The Extension Of Its Application Through Various Technological Approaches. KNOWLEDGE-International Journal. 2018 Dec;28(2):461-8. doi: 10.35120/kij2802461A.

[ ] Rafi MM. Natural curcumin of turmeric origin-the untold story. Natural Products Insider [White Paper]. 2016 Aug:1-11.

[ ] Saffarionpour S, Diosady LL. Curcumin, a potent therapeutic nutraceutical and its enhanced delivery and bioaccessibility by pickering emulsions. Drug Delivery and Translational Research. 2021 Mar 6:1-34. doi: 10.1007/s13346-021-00936-3.

[ ] Jovičić D, Jozinović A, Grčević M, Spaseska Aleksovska E, Šubarić D. Nutritional and health benefits of curcumin. Hrana u zdravlju i bolesti: znanstveno-stručni časopis za nutricionizam i dijetetiku. 2017;6(1):22-7.

[ ] Tsuda T. Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food & function. 2018;9(2):705-14. doi: 10.1039/c7fo01242j.

[ ] Hewlings SJ, Kalman DS. Curcumin: a review of its’ effects on human health. Foods. 2017;6(10):92. doi: 10.3390/foods6100092.

[ ] Xu X-Y, Meng X, Li S, Gan R-Y, Li Y, Li H-B. Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients. 2018;10(10):1553. doi: 10.3390/nu10101553.

[ ] Shanmugam MK, Arfuso F, Sng JC, Bishayee A, Kumar AP, Sethi G. Epigenetic effects of curcumin in cancer prevention. Epigenetics of Cancer Prevention: Elsevier. 2019; p. 107-28. doi:10.1016/B978-0-12-812494-9.00005-6

[ ]Darshini Shah, Reema Savaliya, Pal Patel, Krupa Kansara, Alok Pandya, Alok Dhawan, et al. Curcumin Ag nanoconjugates for improved therapeutic effects in cancer. International Journal of Nanomedicine. 2018;13:75–77. doi:10.2147/IJN.S124696

[ ] Wong KE, Ngai SC, Chan KG, Lee LH, Goh BH, Chuah LH. Curcumin nanoformulations for colorectal cancer: a review. Frontiers in pharmacology. 2019 Mar 5;10:152. doi: 10.3389/fphar.2019.00152.

[ ] Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011 Jun;16(6):4567-98. doi: 10.3390/molecules16064567.

[ ] Mohanty C, Sahoo SK. Curcumin and its topical formulations for wound healing applications. Drug Discovery Today. 2017;22(10):1582-92. doi: 10.1016/j.drudis.2017.07.001. Epub 2017 Jul 12.

[ ] Hussain Z, Thu HE, Ng S-F, Khan S, Katas H. Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art. Colloids and Surfaces B: Biointerfaces. 2017;150:223-41. doi: 10.1016/j.colsurfb.2016.11.036.

[ ] Padmanaban G, Rangarajan PN. Curcumin as an adjunct drug for infectious diseases. Trends in pharmacological sciences. 2016;37(1):1-3. doi: 10.1016/

[ ] da Silva AC, de Freitas Santos PD, do Prado Silva JT, Leimann FV, Bracht L, Gonçalves OH. Impact of curcumin nanoformulation on its antimicrobial activity. Trends in Food Science & Technology. 2018;72:74-82. doi:10.1016/j.tifs.2017.12.004

[ ] Bernardo BC, McMullen JR. Molecular aspects of exercise-induced cardiac remodeling. Cardiology clinics. 2016;34(4):515-30. doi: 10.1016/j.ccl.2016.06.002.

[ ] Yadollahi A, Zargaran B. The Beneficial Effects of Curcumin on Cardiovascular Diseases and Their Risk Factors. Reviews in Clinical Medicine. 2019;6(1):12-9.

[ ] Hashemzaei M, Heravi RE, Rezaee R, Roohbakhsh A, Karimi G. Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders. European journal of pharmacology. 2017;802:44-51. doi: 10.1016/j.ejphar.2017.02.038.

[ ] Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Wozniak, Alicja. Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer. Oxidative Medicine and Cellular Longevity. 2018; 1–14. doi:10.1155/2018/9698258

[ ] Arcaro CA, Gutierres VO, Assis RP, Moreira TF, Costa PI, Baviera AM, et al. Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats. PLoS One. 2014;9(12) e113993. doi: 10.1371/journal.pone.0113993.

[ ] Aziz MTA, El-Asmar MF, El-Ibrashy IN, Rezq AM, Al-Malki AL, Wassef MA, et al. Effect of novel water soluble curcumin derivative on experimental type-1 diabetes mellitus (short term study). Diabetology & Metabolic Syndrome. 2012;4(1):30. doi: 10.1186/1758-5996-4-30.

[ ] Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 2019 Aug;11(8):1837. doi: 10.3390/nu11081837.

[ ] Ganjali S, Blesso CN, Banach M, Pirro M, Majeed M, Sahebkar A. Effects of curcumin on HDL functionality. Pharmacological research. 2017;119:208-18. doi: 10.1016/j.phrs.2017.02.008.

[ ] Bablani P, Shamsi Y, Kapoor P, Sharma M. Anti-Hyperlipidemia Properties of Curcumin. Circulation. 2016;133(16051620):114-008729.

[ ] Moghaddam NSA, Oskouie MN, Butler AE, Petit PX, Barreto GE, Sahebkar A. Hormetic effects of curcumin: What is the evidence? Journal of cellular physiology. 2019;234(7):10060-71. doi: 10.1002/jcp.27880.

[ ] Lv K-J, Chen T-C, Wang G-H, Yao Y-N, Yao H. Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review. Journal of Dermatological Treatment. 2019;30(6):605-11. doi: 10.1080/09546634.2018.1543849.

[ ] Kia SJ, Basirat M, Estakhr L. The effect of oral curcumin on pain and clinical appearance of oral lichen planus. Journal of Dentomaxillofacial. 2017;6(1):1-7.

[ ] Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A. Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Molecular diagnosis & therapy. 2016 Aug;20(4):335-45. doi: 10.1007/s40291-016-0202-7.

[ ] Melekoglu R, Ciftci O, Eraslan S, Cetin A, Basak N. Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model. Journal of ovarian research. 2018;11(1):33. doi: 10.1186/s13048-018-0409-9.

[ ] Sarraf P, Parohan M, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: A systematic review and dose-response meta-analysis of randomized controlled trials. Nutrition Research. 2019 Sep 1;69:1-8. doi: 10.1016/j.nutres.2019.05.001.

[ ] Mahdavi H, Hadadi Z, Ahmadi M. A Review of the Anti-oxidation, Anti-inflammatory and Anti-tumor Properties of Curcumin. Traditional and Integrative Medicine. 2017:188-95.

[ ] Ahangari N, Kargozar S, Ghayour‐Mobarhan M, Baino F, Pasdar A, Sahebkar A, Ferns GA, Kim HW, Mozafari M. Curcumin in tissue engineering: A traditional remedy for modern medicine. BioFactors. 2019 Mar;45(2):135-51. doi: 10.1002/biof.1474.

[ ] Samarghandian S, Azimi-Nezhad M, Farkhondeh T, Samini F. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomedicine & Pharmacotherapy. 2017;87:223-9. doi: 10.1016/j.biopha.2016.12.105.

[ ] Lelli D, Sahebkar A, Johnston TP, Pedone C. Curcumin use in pulmonary diseases: State of the art and future perspectives. Pharmacological research. 2017;115:133-48. doi: 10.1016/j.phrs.2016.11.017.

[ ] Wu S, Xiao D. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Annals of Allergy, Asthma & Immunology. 2016;117(6):697-702. doi: 10.1016/j.anai.2016.09.427.

[ ] Boroumand N, Samarghandian S, Hashemy SI. Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J Herbmed Pharmacol. 2018;7(4). doi: 10.15171/jhp.2018.33.

[ ] Ternullo S, Gagnat E, Julin K, Johannessen M, Basnet P, Vanić Ž, et al. Liposomes augment biological benefits of curcumin for multitargeted skin therapy. European Journal of Pharmaceutics and Biopharmaceutics. 2019;144:154-64. doi: 10.1016/j.ejpb.2019.09.016.

[ ] Kang D, Li B, Luo L, Jiang W, Lu Q, Rong M, et al. Curcumin shows excellent therapeutic effect on psoriasis in mouse model. Biochimie. 2016;123:73-8. doi: 10.1016/j.biochi.2016.01.013.

[ ] Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, et al. Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics. Journal of Clinical Medicine. 2020 Apr;9(4):1061. doi: 10.3390/jcm9041061.

[ ] Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience. 2019 May 15;406:1-21. doi: 10.1016/j.neuroscience.2019.02.020.

[ ] Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A. Effects of curcumin on mitochondria in neurodegenerative diseases. BioFactors. 2020;46(1):5-20. doi: 10.1002/biof.1566.

[ ] Farkhondeh T, Samarghandian S, Samini F. Antidotal effects of curcumin against neurotoxic agents: An updated review. Asian Pacific journal of tropical medicine. 2016;9(10):947-53. doi: 10.1016/j.apjtm.2016.07.027.

[ ] Chin K-Y. The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug design, development and therapy. 2016;10:3029. doi: 10.2147/DDDT.S117432.

[ ] Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. Journal of cellular physiology. 2018;233(6):4497-511. doi: 10.1002/jcp.26249.

[ ] Kim D-C, Ku S-K, Bae J-S. Anticoagulant activities of curcumin and its derivative. BMB reports. 2012;45(4):221-6. doi: 10.5483/bmbrep.2012.45.4.221.

[ ] Silva NA, Sousa N, Reis RL, Salgado AJ. From basics to clinical: a comprehensive review on spinal cord injury. Progress in neurobiology. 2014;114:25-57. doi: 10.1016/j.pneurobio.2013.11.002.

[ ] Zhang Q, Yang H, An J, Zhang R, Chen B, Hao DJ. Therapeutic effects of traditional Chinese medicine on spinal cord injury: a promising supplementary treatment in future. Evidence-Based Complementary and Alternative Medicine. 2016; 1–18. doi:10.1155/2016/8958721

[ ] Al-Hasan MN, Justo JA. Ignoring the elephant: Does the infectious diseases society of America support sepsis-3 or pre-sepsis criteria? Clinical Infectious Diseases. 2019;68(8):1431-37. doi: 10.1093/cid/ciy678.

[ ] Karimi A, Ghodsi R, Kooshki F, Karimi M, Asghariazar V, Tarighat‐Esfanjani A. Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies. Phytotherapy Research. 2019;33(11):2798-820. doi: 10.1002/ptr.6467.

[ ] Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Journal of affective disorders. 2014;167:368-75. doi: 10.1016/j.jad.2014.06.001.

[ ] Brietzke E, Mansur RB, Zugman A, Carvalho AF, Macêdo DS, Cha DS, et al. Is there a role for curcumin in the treatment of bipolar disorder? Medical hypotheses. 2013;80(5):606-12. doi: 10.1016/j.mehy.2013.02.001.

[ ] Bhat A, Mahalakshmi AM, Ray B, Tuladhar S, Hediyal TA, Manthiannem E, Padamati J, Chandra R, Chidambaram SB, Sakharkar MK. Benefits of curcumin in brain disorders. BioFactors. 2019 Sep;45(5):666-89. doi: 10.1002/biof.1533.

[ ] Shen L, Liu L, Ji H-F. Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Food & nutrition research. 2017;61(1):1361780. doi: 10.1080/16546628.2017.1361780.

[ ] Tung BT, Nham DT, Hai NT, Thu DK. Curcuma longa, the Polyphenolic Curcumin Compound and Pharmacological Effects on Liver. Dietary Interventions in Liver Disease Elsevier. 2019; 125-34. doi:10.1016/B978-0-12-814466-4.00010-0

[ ] Bavarsad K, Riahi MM, Saadat S, Barreto G, Atkin SL, Sahebkar A. Protective effects of curcumin against ischemia-reperfusion injury in the liver. Pharmacological research. 2019;141:53-62. doi: 10.1016/j.phrs.2018.12.014.

[ ] Ellerkamp V, Bortel N, Schmid E, Kirchner B, Armeanu-Ebinger S, Fuchs J. Photodynamic therapy potentiates the effects of curcumin on pediatric epithelial liver tumor cells. Anticancer research. 2016;36(7):3363-72. PMID: 27354595

[ ] Gheibi S, Ghaleh HEG, Motlagh BM, Azarbayjani AF. Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease. Biomedicine & Pharmacotherapy. 2019;115:108938. doi: 10.1016/j.biopha.2019.108938.

[ ] Rachmawati H, Novel MA, Nisa RM, Berlian G, Tandrasasmita OM, Rahma A, et al. Co-delivery of curcumin-loaded nanoemulsion and Phaleria macrocarpa extract to NIH 3T3 cell for antifibrosis. Journal of Drug Delivery Science and Technology. 2017 Jun;39:123-30. doi:10.1016/j.jddst.2017.03.015

[ ] Bagherniya M, Nobili V, Blesso CN, Sahebkar A. Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review. Pharmacological Research. 2018 Apr ;130:213-40. doi: 10.1016/j.phrs.2017.12.020.

[ ] Azhdari M, Karandish M, Mansoori A. Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy research. 2019;33(5):1289-301. doi: 10.1002/ptr.6323.

[ ] Yang M, Akbar U, Mohan C. Curcumin in autoimmune and rheumatic diseases. Nutrients. 2019 May;11(5):1004. doi: 10.3390/nu11051004.




How to Cite

Arif, A., Fatima, M., & Mehmood, S. (2020). Therapeutic Potential of Curcumin in Curcuma Longa: Therapeutic Potential of Curcumin in Curcuma longa. DIET FACTOR (Journal of Nutritional &Amp; Food Sciences), 1(02), 13–22.



Review Article